Monday, August 6, 2012

Inside Funny Or Die?s Viral Video Machine

images (4)In a digital world of one-hit wonders, Funny or Die is the Beatles of the Internet, churning out viral hit after viral hit. As a result, the celebrity-laden sketch comedy site has become an oasis of financial success in an online video industry still dominated by garage directors struggling to make premium content. What's the secret sauce behind their viral machine? First, give your talent some creative flexibility: act more like an editor than a director. Second, viral sharing thrives on topical subjects and the just-barely-believable. Finally, funny is funny: never sacrifice quality for quantity.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/T2cunzXiEYI/

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Saturday, July 28, 2012

Landmark HIV treatment-as-prevention study shows additional health benefits, cost-effectiveness

Landmark HIV treatment-as-prevention study shows additional health benefits, cost-effectiveness [ Back to EurekAlert! ] Public release date: 27-Jul-2012
[ | E-mail | Share Share ]

Contact: Kathy Stover
niaidnews@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases

WHAT: Further analyses of the landmark NIH-funded treatment-as-prevention study (HPTN 052) have found that providing antiretroviral treatment to HIV-infected individuals earlier, when their immune systems are healthier, delays AIDS-related health events, such as chronic herpes simplex virus and tuberculosis, as well as death. Additionally, researchers found that earlier HIV treatment is also cost-effective because it increases survival, prevents costly opportunistic infections and averts transmission of the virus to uninfected individuals.

The two analyses were presented at the XIX International AIDS Conference (AIDS 2012) in Washington, D.C. The health benefits talk was presented by Beatriz Grinsztejn, M.D., HPTN site investigator for the Instituto de Pesquisa Clinica Evandro Chagas in Brazil. The cost-effectiveness talk was given by Kenneth A. Freedberg, M.D., MSc, an associate professor of medicine at Harvard Medical School and director of the Program in Epidemiology and Outcomes Research at the Harvard Medical School's Division of AIDS.

Initial results from the HPTN 052 study, announced in 2011, demonstrated that earlier use of antiretrovirals by HIV-infected heterosexuals partnered with uninfected individuals (serodiscordant couples) reduced HIV transmission by 96 percent. In two years of follow-up analysis of 1,761 HIV-infected study participants, researchers compared those who delayed antiretroviral treatment until their CD4+ T-cell counts were an average of 230 cells/ per cubic millimeter (mm) with those who began antiretroviral treatment sooner (an average CD4 level of 440 cells/ mm). The delayed group experienced a shorter time to a primary clinical event, including AIDS-defining disease and all types of tuberculosis. In total, there were 91 primary clinical events in the delayed treatment group versus 71 in the immediate group. This included 71 cases of AIDS-defining disease in the delayed treatment group versus 49 in the immediate group, and 34 cases of tuberculosis in the delayed group versus 17 in the immediate group. The trial provides evidence that earlier antiretroviral treatment among the HIV-infected provides significant health benefits.

In a separate modeling analysis designed to predict the clinical impact, costs and cost-effectiveness of the earlier antiretroviral treatment strategy, researchers compared the delayed treatment (CD4 counts of less than 250 cells/mm) versus earlier treatment (350-550 cells/ mm) data in South Africa and India. The two countries were selected to show how regional economic differences may or may not affect the conclusions. The researchers designated earlier treatment to be "very cost effective" if its cost-effectiveness ratio was less than one times per capita gross domestic product (GDP). Earlier treatment was deemed "cost effective" if its cost-effectiveness ratio was less than three times per capita GDP. The GDP was set at $8,100 for South Africa and $1,400 for India.

Using this model, they found that in both South Africa and India early ART increases patient survival, prevents costly opportunistic infectionspartially offsetting the costs of treatmentaverts HIV transmission, and is cost-effective within a five-year span and very cost-effective over a lifetime.

###

The HPTN 052 study and its follow-up analyses were funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. They were conducted by the NIH-funded HIV Prevention Trials Network.

WHO: NIAID Director Anthony S. Fauci, M.D., and Carl W. Dieffenbach, Ph.D., director of NIAID's Division of AIDS, are available to comment.

CONTACT: To schedule interviews, please contact Kathy Stover, (301) 402-1663, niaidnews@niaid.nih.gov.

NIAID conducts and supports researchat NIH, throughout the United States, and worldwideto study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov/.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Landmark HIV treatment-as-prevention study shows additional health benefits, cost-effectiveness [ Back to EurekAlert! ] Public release date: 27-Jul-2012
[ | E-mail | Share Share ]

Contact: Kathy Stover
niaidnews@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases

WHAT: Further analyses of the landmark NIH-funded treatment-as-prevention study (HPTN 052) have found that providing antiretroviral treatment to HIV-infected individuals earlier, when their immune systems are healthier, delays AIDS-related health events, such as chronic herpes simplex virus and tuberculosis, as well as death. Additionally, researchers found that earlier HIV treatment is also cost-effective because it increases survival, prevents costly opportunistic infections and averts transmission of the virus to uninfected individuals.

The two analyses were presented at the XIX International AIDS Conference (AIDS 2012) in Washington, D.C. The health benefits talk was presented by Beatriz Grinsztejn, M.D., HPTN site investigator for the Instituto de Pesquisa Clinica Evandro Chagas in Brazil. The cost-effectiveness talk was given by Kenneth A. Freedberg, M.D., MSc, an associate professor of medicine at Harvard Medical School and director of the Program in Epidemiology and Outcomes Research at the Harvard Medical School's Division of AIDS.

Initial results from the HPTN 052 study, announced in 2011, demonstrated that earlier use of antiretrovirals by HIV-infected heterosexuals partnered with uninfected individuals (serodiscordant couples) reduced HIV transmission by 96 percent. In two years of follow-up analysis of 1,761 HIV-infected study participants, researchers compared those who delayed antiretroviral treatment until their CD4+ T-cell counts were an average of 230 cells/ per cubic millimeter (mm) with those who began antiretroviral treatment sooner (an average CD4 level of 440 cells/ mm). The delayed group experienced a shorter time to a primary clinical event, including AIDS-defining disease and all types of tuberculosis. In total, there were 91 primary clinical events in the delayed treatment group versus 71 in the immediate group. This included 71 cases of AIDS-defining disease in the delayed treatment group versus 49 in the immediate group, and 34 cases of tuberculosis in the delayed group versus 17 in the immediate group. The trial provides evidence that earlier antiretroviral treatment among the HIV-infected provides significant health benefits.

In a separate modeling analysis designed to predict the clinical impact, costs and cost-effectiveness of the earlier antiretroviral treatment strategy, researchers compared the delayed treatment (CD4 counts of less than 250 cells/mm) versus earlier treatment (350-550 cells/ mm) data in South Africa and India. The two countries were selected to show how regional economic differences may or may not affect the conclusions. The researchers designated earlier treatment to be "very cost effective" if its cost-effectiveness ratio was less than one times per capita gross domestic product (GDP). Earlier treatment was deemed "cost effective" if its cost-effectiveness ratio was less than three times per capita GDP. The GDP was set at $8,100 for South Africa and $1,400 for India.

Using this model, they found that in both South Africa and India early ART increases patient survival, prevents costly opportunistic infectionspartially offsetting the costs of treatmentaverts HIV transmission, and is cost-effective within a five-year span and very cost-effective over a lifetime.

###

The HPTN 052 study and its follow-up analyses were funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. They were conducted by the NIH-funded HIV Prevention Trials Network.

WHO: NIAID Director Anthony S. Fauci, M.D., and Carl W. Dieffenbach, Ph.D., director of NIAID's Division of AIDS, are available to comment.

CONTACT: To schedule interviews, please contact Kathy Stover, (301) 402-1663, niaidnews@niaid.nih.gov.

NIAID conducts and supports researchat NIH, throughout the United States, and worldwideto study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov/.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-07/nioa-lht072712.php

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Friday, July 27, 2012

Frank Pierson 1925 - 2012 | Flickr - Photo Sharing!

Hollywood director and screenwriter who won an Oscar for Dog Day Afternoon

In Sunset Boulevard, William Holden's character remarks: "Audiences don't know somebody sits down and writes a picture. They think the actors make it up as they go along." Given the difficulties in quantifying their contributions, screenwriters seldom get the recognition they deserve. Frank Pierson, who has died aged 87, wrote the screenplays for 10 films but his reputation rests on Cat Ballou (1965), Cool Hand Luke (1967) and Dog Day Afternoon (1975), all of which gained him Academy Award nominations, with the last of them winning the Oscar for best original screenplay.

Yet most of the plaudits for Dog Day Afternoon went to Sidney Lumet, the director, and Al Pacino, the star. Pierson, whose work had as much to do with structure and character as dialogue, shaped the script from a Life magazine article about a bungled bank robbery that took place on a hot summer's day in New York in 1972. At first, Pierson found it difficult to write about the man played by Pacino: "It took me several months before I was able to conceive of him, because until you have a character whose motivations you understand, there's no way of writing him consistently."

Much of the film's anti-establishment tone (including the repetition of the countercultural war cry "Attica!", in reference to the 1971 Attica prison riots) and its intensity (it takes place over a single afternoon and evening), derives from the script, as does the humour and complexity of Pacino's character (he attempts the robbery to pay for his gay lover's sex change operation).

Pierson was born in Chappaqua, New York, the son of Harold Pierson, an entrepreneur, and Louise Randall Pierson, a proto-feminist writer, portrayed by Rosalind Russell in the 1945 film Roughly Speaking, which was based on her autobiography. Pierson served in the army during the second world war, then went to Harvard, where he received a degree in cultural anthropology. Following a spell as entertainment correspondent for Time magazine, he moved to Hollywood, where he wrote 11 episodes (1959-61) of the television horse opera Have Gun ? Will Travel. He was soon given a chance to write a movie script. The screenplay of Cat Ballou, written with the more experienced Walter Newman, kept the structure of Roy Chanslor's novel, The Ballad of Cat Ballou, from which the movie was loosely adapted.

Directed by Elliot Silverstein, Cat Ballou was an amusing spoof western starring Jane Fonda, with Lee Marvin in a double role as a murderous hired gun and his twin brother, a grizzled alcoholic old gunfighter who, when informed that his eyes are bloodshot, replies: "You ought to see 'em from my side." Marvin, allowed to exploit his hitherto untapped comic gifts, won the Oscar for best actor. The film started a mode for comic westerns, a genre that had been moribund since the days of Bob Hope.

Pierson was then brought in by Silverstein to doctor the script of The Happening (1967), about a gangster (played by Anthony Quinn) who is kidnapped by hippy beach bums. In the same year, he was co-credited as writer on Cool Hand Luke, with Donn Pearce, who wrote the original novel.

One of the key American films of the period, directed by Stuart Rosenberg and starring Paul Newman in the title role, Cool Hand Luke was a violent but less dark and more irreverent chaingang movie than most. Particularly memorable was the contest in which Luke eats 50 hardboiled eggs on a bet, and the brutal boxing match between the hero and his nemesis, fellow convict Dragline (George Kennedy), which seems to interpret Luke's masochism as his invincible spirit. Dragline is no one-dimensional brute, and comes to admire his adversary. "That's my darlin' Luke," he says. "He grin like a baby, but he bites like a gator." Another line, delivered to Luke by the prison captain (Strother Martin), proved resonant: "What we've got here is ? failure to communicate." Spoken first by a redneck, it has a humorous effect. Newman repeats the line at the film's climax.

Pierson then directed his first feature, The Looking Glass War (1969), based on John le Carr?'s cold war spy novel. His screenplay, in keeping with the demands of a young audience, changed the novel's hero, a retired, ageing Polish spy, into a young Polish hustler (played by 28-year-old Christopher Jones, a counterculture star at the time), eager to defect to the west so he can live in London with his pregnant girlfriend (Susan George). The ably directed film benefited greatly from a sterling British cast including Ralph Richardson and Anthony Hopkins.

Pierson's first collaboration with Lumet was The Anderson Tapes (1971), an intriguing heist movie starring Sean Connery, and arguably the first film to cover the subject of surveillance devices. After the triumph of Dog Day Afternoon, Pierson had the misfortune to be involved with Barbra Streisand and her producer boyfriend Jon Peters on A Star Is Born (1976), the second remake of the 1937 William Wellman movie, with a contemporary soundtrack. This collaboration, on which Pierson was director and fifth screenwriter, was detailed in an article in the Village Voice entitled My Battles with Barbra and Jon, one of the most revelatory behind-the-scenes accounts of film-making. Unfortunately, his battles, mainly with the temperamental star, resulted in a defeat, as the film turned out to be a vanity project, though Streisand was impressive belting out the tunes.

Pierson's third and last film as director was King of the Gypsies (1978), which offered a fascinating glimpse into an exotic folklore. Because he was busy serving as president of the Writers Guild of America (1981-83) and working as a television producer, it was 11 years before he returned to screenwriting with Norman Jewison's In Country (1989), a rather sentimental, meandering tale starring Bruce Willis as a disturbed Vietnam veteran. Pierson managed to maintain the tension in his script for Alan J Pakula's Presumed Innocent (1990), an engrossing thriller based on Scott Turow's bestseller and featuring Harrison Ford.

Pierson, who was president of the Academy of Motion Picture Arts and Sciences from 2001 to 2005, ended his career on a high as consulting producer on the television series Mad Men.

His first two marriages, to Polly Stokes and Dori Derfner, ended in divorce. He is survived by Helene, whom he married in 1990, and his children, Michael and Eve, from his first marriage.

? Frank Romer Pierson, screenwriter, producer and director, born 12 May 1925; died 22 July 2012

Ronald Bergan The Guardian 26 July 2012

Source: http://www.flickr.com/photos/greenman2008/7653029838/

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Cheap MBT Kesho MJ Women's Black Shoes on sale | Uta Que Rico!

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Source: http://www.utaquerico.com/?q=node/15239

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Thursday, July 26, 2012

Did shooting suspect send plans to doctor?

AURORA, Colo. (Reuters) - The man accused of Friday's movie theater massacre in Colorado mailed a notebook "full of details about how he was going to kill people" to a University of Colorado psychiatrist before the attack, FoxNews.com reported on Wednesday.

The package allegedly from the suspected shooter, 24-year-old James Eagan Holmes, remained unopened in a mailroom for as long as a week before its discovery Monday, FoxNews.com reported, citing a law enforcement source.

[Complete coverage of Colorado shooting]

Reuters could not immediately verify the report but was seeking to do so. Messages left with police in Aurora and other law enforcement officials involved in the case were not immediately returned.

The FoxNews.com report said Police and FBI agents were called to the University of Colorado Anschutz medical campus in Aurora on Monday morning after the psychiatrist, who is also a professor at the school, reported receiving a package believed to be from the suspect.

?

Although that package turned out to be from someone else and harmless, a search of the Campus Services' mailroom turned up another package sent to the psychiatrist with Holmes' name in the return address, the source told FoxNews.com.

After obtaining a search warrant, police took the package away and discovered its contents.

FoxNews.com quoted its source saying: "Inside the package was a notebook full of details about how he was going to kill people. There were drawings of what he was going to do in it - drawings and illustrations of the massacre."

Police say Holmes, wearing body armor, a gas mask and toting three firearms, opened fire on a crowded midnight screening of "The Dark Knight Rises" in the Denver suburb of Aurora, killing 12 people and wounding 58 others.

Holmes, who was arrested immediately after the attack outside the theater, made his first appearance in court on Monday. Authorities plan to formally charge him on July 30.

?(Reporting by Dan Burns; Editing by Vicki Allen)

Source: http://news.yahoo.com/report-colorado-shooting-suspect-sent-plans-notebook-psychiatrist-170815999.html

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Home Staging Tips From A Pro- Sell Your Palm Springs Home Faster

The information being provided by CARETS (CLAW, CRISNet MLS, DAMLS, CRMLS, i-Tech MLS, and/or VCRDS) is for the visitor's personal, non-commercial use and may not be used for any purpose other than to identify prospective properties visitor may be interested in purchasing.

Any information relating to a property referenced on this web site comes from the Internet Data Exchange (IDX) program of CARETS. This web site may reference real estate listing(s) held by a brokerage firm other than the broker and/or agent who owns this web site.

The accuracy of all information, regardless of source, including but not limited to square footages and lot sizes, is deemed reliable but not guaranteed and should be personally verified through personal inspection by and/or with the appropriate professionals. The data contained herein is copyrighted by CARETS, CLAW, CRISNet MLS, DAMLS, CRMLS, i-Tech MLS and/or VCRDS and is protected by all applicable copyright laws. Any dissemination of this information is in violation of copyright laws and is strictly prohibited.

CARETS, California Real Estate Technology Services, is a consolidated MLS property listing data feed comprised of CLAW (Combined LA/Westside MLS), CRISNet MLS (Southland Regional AOR), DAMLS (Desert Area MLS), CRMLS (California Regional MLS), i-Tech MLS (Glendale AOR/Pasadena Foothills AOR) and VCRDS (Ventura County Regional Data Share).

Date last updated: 7/24/12 4:27 PM PDT

This IDX solution is (c) Diverse Solutions 2012.

Source: http://www.talkingrealestatepalmsprings.com/home-staging-tips/

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